Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | CAD | P27708 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12962517 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL21436951 | 0.81 | EPHX1 (0.38) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL23002170 | 0.79 | POLB (0.35) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL17925905 | 0.78 | ALDH1A1 (0.38) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL14827814 | 0.77 | CRBN (0.33) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL6405736 | 0.76 | ITGB1 (0.43) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL6405731 | 0.76 | ITGB1 (0.43) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL25851247 | 0.74 | ALDH1A1 (0.38) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL16876469 | 0.74 | MEN1 (0.41) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL23002182 | 0.71 | ALDH1A1 (0.39) | ITGB1ITGA5ITGB3ITGB2ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151252-B | Iron death inhibitor-diarylamine acetamides | 维泰瑞隆有限公司 | 2024-08-27 | — | — | CN | disclosed |
| US-20230227405-A1 | 5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-07-20 | — | — | US | disclosed |
| US-20230159492-A1 | FERROPTOSIS INHIBITORS - DIARYLAMINE PARA-ACETAMIDES | Sironax Ltd. (KY) | 2023-05-25 | — | — | US | disclosed |
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED | 2023-01-19 | — | — | US | disclosed |
| EP-4114375-A1 | FERROPTOSIS INHIBITORS-DIARYLAMINE PARA-ACETAMIDES | Sironax Ltd (KY) | 2023-01-11 | — | — | EP | disclosed |
| CN-115151252-A | Iron death inhibitors diarylamine para-acetamides | 维泰瑞隆有限公司 | 2022-10-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, APOB, NPC1L1 | ITGB1 663/4885ITGA5 2260/4885ITGB3 2019/4885 |
| US-20230227405-A1 | 5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS | SCN8A, TRPV1, SCN5A | ITGB1 3839/4885ITGA5 2299/4885ITGB3 3960/4885 |
| US-20230159492-A1 | FERROPTOSIS INHIBITORS - DIARYLAMINE PARA-ACETAMIDES | AIFM2, FECH, GPX4 | ITGB1 4812/4885ITGA5 4806/4885ITGB3 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.