SCHEMBL2490872

SCHEMBL2490872

O=C(O)c1cc(Cn2nnc(C(F)(F)C(F)(F)C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC16A3 O15427 13/20 0.33
SLC16A1 P53985 12/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
CASP3 P42574 1/20 0.33
SENP8 Q96LD8 1/20 0.33
MARS1 P56192 1/20 0.32
MCTS1 Q9ULC4 7/20 0.31
HDAC3 O15379 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC11 Q96DB2 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2785709 0.93 SLC16A3 (0.32) SLC16A3SLC16A1HDAC3HDAC4HDAC1
SCHEMBL2134837 0.91 NPC1 (0.35) SLC16A3SLC16A1NPC1RAB9ASMN1; SMN2
SCHEMBL2490874 0.87 SLC16A3 (0.34) SLC16A3SLC16A1MCTS1TRPA1TRPV1
SCHEMBL2491219 0.85 TRPA1 (0.33) SLC16A3SLC16A1MCTS1TRPA1TRPV1
SCHEMBL24287198 0.83 TRPA1 (0.34) SLC16A3SLC16A1NPC1RAB9ASMN1; SMN2
SCHEMBL30388183 0.82 SCN9A (0.36) SLC16A3SLC16A1NPC1RAB9ASMN1; SMN2
SCHEMBL2131820 0.81 RXRA (0.36) SLC16A3SLC16A1MCTS1TRPA1TRPV1
SCHEMBL30206525 0.81 HDAC6 (0.49) NPC1RAB9ASMN1; SMN2CASP3SENP8
SCHEMBL24950045 0.81 HDAC6 (0.49) NPC1RAB9ASMN1; SMN2CASP3SENP8
SCHEMBL15488988 0.81 ALDH1A1 (0.32) SMN1; SMN2MARS1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379526-B1 Tetrazol-substituted anthranilic acid amides as pesticides BAYER IP GMBH (DE) 2015-05-27 EP disclosed
EP-2484676-B1 Tetrazol-substituted anthranilic acid amides as pesticides BAYER CROPSCIENCE AG (DE) 2015-01-21 EP disclosed
EP-2484676-B1 Tetrazol-substituted anthranilic acid amides as pesticides BAYER CROPSCIENCE AG (DE) 2015-01-21 EP disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
EP-2484676-A2 Tetrazol-substituted anthranilic acid amides as pesticides Bayer CropScience AG (DE) 2012-08-08 EP disclosed
EP-2379526-A2 TETRAZOLE SUBSTITUTED ANTHRANILIC ACID AMIDES AS PESTICIDES Bayer CropScience AG (DE) 2011-10-26 EP disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
WO-2010069502-A2 TETRAZOLE SUBSTITUTED ANTHRANILIC ACID AMIDES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2010-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides ANTXR2, PNISR, H1-5 SLC16A3 1919/4885SLC16A1 2291/4885NPC1 4044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.