SCHEMBL24909353

SCHEMBL24909353

CC(C)(C)c1ncc(-c2cc(C#N)cc(C(F)(F)F)c2O)o1

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 2/20 0.32
LRRK2 Q5S007 1/20 0.32
TRPV4 Q9HBA0 1/20 0.32
XDH P47989 1/20 0.31
SLC22A12 Q96S37 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31
PIK3CA P42336 1/20 0.31
TTR P02766 1/20 0.30
ALB P02768 1/20 0.30
AR P10275 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909944 0.85 PDK2 (0.37) PIK3CGLRRK2TRPV4XDHSLC22A12
SCHEMBL24909798 0.74 ALOX5AP (0.34) LRRK2TRPV4TTRALB
SCHEMBL24909337 0.73 XDH (0.36) PIK3CGTRPV4XDHSLC22A12PIK3CA
SCHEMBL24910046 0.73 XDH (0.39) PIK3CGTRPV4XDHSLC22A12PIK3CA
SCHEMBL24909746 0.71 GYS1 (0.35) LRRK2TRPV4XDHSLC22A12TTR
SCHEMBL24909900 0.70 LRRK2 (0.35) LRRK2TRPV4XDHSLC22A12TTR
SCHEMBL24909411 0.69 GRM5 (0.42) LRRK2
SCHEMBL24909924 0.68 AKR1C3 (0.41) TRPV4XDHSLC22A12AR
SCHEMBL24909734 0.68 AURKA (0.39) TRPV4XDHSLC22A12TTRALB
SCHEMBL24909915 0.67 KIF11 (0.41) TRPV4XDHSLC22A12TTRALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 PIK3CG 2532/4885LRRK2 2146/4885TRPV4 2634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.