SCHEMBL24909411

SCHEMBL24909411

N#Cc1cc(-c2cnccn2)c(O)c(C(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.42
KDM4C Q9H3R0 1/20 0.35
PIEZO1 Q92508 3/20 0.33
CYP3A4 P08684 2/20 0.33
CYP3A5 P20815 2/20 0.33
HCRTR1 O43613 1/20 0.33
HCRTR2 O43614 1/20 0.33
EGFR P00533 1/20 0.33
P2RX7 Q99572 1/20 0.33
TSHR P16473 1/20 0.32
PORCN Q9H237 1/20 0.32
HSD17B10 Q99714 1/20 0.32
ERN1 O75460 1/20 0.32
WNT3A P56704 1/20 0.32
LRRK2 Q5S007 1/20 0.32
GYS1 P13807 1/20 0.32
SCN9A Q15858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909798 0.81 ALOX5AP (0.34) GRM5LRRK2GYS1
SCHEMBL24909900 0.76 LRRK2 (0.35) LRRK2GYS1
SCHEMBL24909746 0.75 GYS1 (0.35) LRRK2GYS1
SCHEMBL24909935 0.74 KIF11 (0.36) ERN1WNT3AGYS1SCN9A
SCHEMBL24909416 0.74 CYP11B2 (0.36) LRRK2
SCHEMBL24909792 0.73 CYP11B2 (0.45) CYP3A4CYP3A5ERN1GYS1
SCHEMBL24909752 0.73 ELANE (0.35) LRRK2GYS1
SCHEMBL31097123 0.73 CRHR1 (0.41) GYS1
SCHEMBL23621186 0.73 CRHR1 (0.41) GYS1
SCHEMBL24910087 0.73 TRPV4 (0.34) KDM4CGYS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 GRM5 1444/4885KDM4C 188/4885PIEZO1 3976/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.