Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 8/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923473 | 1.00 | PLA2G2A (0.53) | PLA2G2ABACE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL16832843 | 0.84 | PLA2G2A (0.69) | PLA2G2ABACE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL2910558 | 0.84 | PLA2G2A (0.54) | PLA2G2ABACE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL28130384 | 0.83 | KDM4E (0.68) | PLA2G2ABACE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL1694287 | 0.81 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1HPGDPOLB | |
| SCHEMBL32681649 | 0.81 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1HPGDPOLB | |
| SCHEMBL28559497 | 0.80 | PLA2G2A (0.62) | PLA2G2AKDM4EALDH1A1NPSR1MEN1 | |
| SCHEMBL13234529 | 0.79 | KCNH2 (0.51) | PLA2G2ABACE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL28491584 | 0.78 | GRM2 (0.57) | PLA2G2ABACE1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL28130383 | 0.77 | PLA2G2A (0.67) | PLA2G2AKDM4EHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-B1 | WDR5 INHIBITORS AND MODULATORS | UNIV VANDERBILT (US) | 2024-03-20 | — | — | EP | disclosed |
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | PLA2G2A 3521/4885BACE1 4107/4885KDM4E 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.