Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.62 |
| ▸ | FEN1 | P39748 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056976 | 0.92 | KMT2A (0.60) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL24209665 | 0.89 | MMP1 (0.60) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL600674 | 0.86 | ERCC5 (0.72) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL28771856 | 0.82 | ERCC5 (0.67) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL6820156 | 0.81 | GSK3B (0.57) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL27745056 | 0.80 | BLM (0.61) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL10789236 | 0.80 | TSHR (0.55) | MAPTKDM4EALDH1A1ERCC5FEN1 | |
| SCHEMBL4716770 | 0.80 | ERCC5 (0.70) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL29113253 | 0.80 | ERCC5 (0.64) | L3MBTL1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL10788517 | 0.79 | NPC1 (0.55) | L3MBTL1MAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4356971-A2 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2024-04-24 | — | — | EP | disclosed |
| CN-102256972-A | Thiazolyl-benzimidazoles | HOFFMANN LA ROCHE | 2011-11-23 | — | — | CN | disclosed |
| EP-2379543-A2 | THIAZOLYL-BENZIMIDAZOLES | F. Hoffmann-La Roche AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| US-8044213-B2 | Thiazolyl-benzimidazoles | HOFFMANN-LA ROCHE INC. (US) | 2011-10-25 | — | — | US | disclosed |
| WO-2010121675-A2 | THIAZOLYL-BENZIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CAI JIANPING | 2010-06-24 | — | — | US | disclosed |
| US-7049271-B2 | Phenyl-substituted 2-enamino-ketonitriles | BAYER AKTIENGESELLSCHAFT (DE) | 2006-05-23 | — | — | US | disclosed |
| US-20060100106-A1 | Phenyl-substituted 2-enamino-ketonitriles | FISCHER REINER | 2006-05-11 | — | — | US | disclosed |
| US-20030220196-A1 | Phenyl-substituted-2enamino-keto nitriles | BAYER AKTIENGESELLSCHAFT (DE) | 2003-11-27 | — | — | US | disclosed |
| EP-1286956-A1 | PHENYL-SUBSTITUTED 2-ENAMINO-KETO NITRILES | Bayer CropScience AG (DE) | 2003-03-05 | — | — | EP | disclosed |
| US-4160095-A | PROSTAGLANDINS; ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1979-07-03 | — | — | US | disclosed |
| US-4157441-A | PROSTAGLANDINS, ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1979-06-05 | — | — | US | disclosed |
| US-4151351-A | PROSTAGLANDINS, ANTIINFLAMMATORY | THE UPJOHN COMPANY (US) | 1979-04-24 | — | — | US | disclosed |
| US-4131738-A | 6-Hydroxy-PGE1 compounds | THE UPJOHN COMPANY (US) | 1978-12-26 | — | — | US | disclosed |
| US-4128713-A | 6,7-Didehydro-PGI1 compounds | THE UPJOHN COMPANY (US) | 1978-12-05 | — | — | US | disclosed |
| US-4126744-A | PROSTACYCLIN, MUSCLE STIMULANTS, PLATELET AGGREGATION INHIBITORS | THE UPJOHN COMPANY (US) | 1978-11-21 | — | — | US | disclosed |
| US-4112224-A | PROSTAGLANDIN | THE UPJOHN COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-4109082-A | PROSTACYCLIN ANALOGS; SMOOTH MUSCLE STIMULATORS | THE UPJOHN COMPANY (US) | 1978-08-22 | — | — | US | disclosed |
| US-4100192-A | Inter-phenylene-PG amides | THE UPJOHN COMPANY (US) | 1978-07-11 | — | — | US | disclosed |
| US-4097489-A | PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1978-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100106-A1 | Phenyl-substituted 2-enamino-ketonitriles | AR, KCNK4, KCNA1 | L3MBTL1 1549/4885MAPT 2895/4885KDM4E 86/4885 |
| US-20030220196-A1 | Phenyl-substituted-2enamino-keto nitriles | CYP1A1, CYP4X1, KCNK4 | L3MBTL1 2952/4885MAPT 4153/4885KDM4E 128/4885 |
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CYP3A7, CYP2C19, CYP3A5 | L3MBTL1 3839/4885MAPT 1573/4885KDM4E 3163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.