⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479599 | 0.71 | TSHR (0.56) | — | |
| SCHEMBL9629249 | 0.69 | KDM4E (0.54) | — | |
| SCHEMBL29954067 | 0.69 | RAB9A (0.59) | — | |
| SCHEMBL2556315 | 0.67 | PDPK1 (0.41) | — | |
| SCHEMBL9630548 | 0.66 | ALOX5 (0.62) | — | |
| SCHEMBL2558370 | 0.66 | HSD17B1 (0.42) | — | |
| SCHEMBL9629237 | 0.66 | ALOX5 (0.62) | — | |
| SCHEMBL1460034 | 0.65 | CDC7 (0.56) | — | |
| SCHEMBL28523576 | 0.65 | HSD17B1 (0.47) | — | |
| SCHEMBL24920104 | 0.64 | KDM4E (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240336634-A1 | AGONISTS OF TYRO3 AS PROTECTION AGAINST PODOCYTE INJURY IN KIDNEY GLOMERULAR DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2024-10-10 | — | — | US | disclosed |
| WO-2023004138-A1 | AGONISTS OF TYRO3 AS PROTECTION AGAINST PODOCYTE INJURY IN KIDNEY GLOMERULAR DISEASE | DAS BHASKAR (US) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023004138-A1 | AGONISTS OF TYRO3 AS PROTECTION AGAINST PODOCYTE INJURY IN KIDNEY GLOMERULAR DISEASE | DAS BHASKAR (US) | 2023-01-26 | — | — | WO | disclosed |