Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HLCS | P50747 | 1/20 | 0.31 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.30 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113037 | 0.76 | PDE4A (0.33) | LMNAALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL3117803 | 0.76 | PDE4A (0.33) | LMNAALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL24919839 | 0.74 | ALDH1A1 (0.36) | NAAAALDH1A1L3MBTL1CCR2PDE4A | |
| SCHEMBL24493598 | 0.73 | ALDH1A1 (0.35) | NAAAALDH1A1L3MBTL1CCR2PDE4A | |
| SCHEMBL268203 | 0.72 | TSHR (0.37) | LMNAALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL21587611 | 0.72 | TSHR (0.37) | LMNAALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL522950 | 0.72 | TSHR (0.37) | LMNAALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL18595192 | 0.72 | LMNA (0.38) | NAAALMNAALDH1A1DAGLACYP1A2 | |
| SCHEMBL18595269 | 0.72 | LMNA (0.38) | NAAALMNAALDH1A1DAGLACYP1A2 | |
| SCHEMBL18595310 | 0.72 | LMNA (0.38) | NAAALMNAALDH1A1DAGLACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | PIK3CA, PIK3CG, PIK3CD | NAAA 3640/4885LMNA 4493/4885ALDH1A1 3899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.