SCHEMBL24920087

SCHEMBL24920087

CC1SC(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)=NC1=O

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LIPG Q9Y5X9 13/20 0.46
LPL P06858 12/20 0.46
CA1 P00915 3/20 0.38
CA2 P00918 3/20 0.38
CA9 Q16790 3/20 0.38
CA12 O43570 1/20 0.38
CA3 P07451 1/20 0.38
CA4 P22748 1/20 0.38
CA6 P23280 1/20 0.38
CA5A P35218 1/20 0.38
CA7 P43166 1/20 0.38
CA14 Q9ULX7 1/20 0.38
CA5B Q9Y2D0 1/20 0.38
SNCA P37840 1/20 0.37
F11 P03951 1/20 0.34
P4HB P07237 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24920082 0.78 LPL (0.31) LIPGLPL
SCHEMBL24920078 0.78 SNCA (0.32) SNCA
SCHEMBL24920105 0.76 PRMT5 (0.34) LIPGLPL
SCHEMBL24920081 0.75
SCHEMBL24920106 0.75 PRMT5 (0.36) LIPGLPL
SCHEMBL24608995 0.71 LIPG (0.83) LIPGLPLCA1CA2CA9
SCHEMBL2707320 0.71 LIPG (0.83) LIPGLPLCA1CA2CA9
SCHEMBL228212 0.69 LPL (0.71) LIPGLPLCA1CA2CA9
SCHEMBL19933573 0.67 LIPG (0.63) LIPGLPLCA1CA2CA9
SCHEMBL28389622 0.66 LIPG (0.88) LIPGLPLCA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023004138-A1 AGONISTS OF TYRO3 AS PROTECTION AGAINST PODOCYTE INJURY IN KIDNEY GLOMERULAR DISEASE DAS BHASKAR (US) 2023-01-26 WO disclosed