SCHEMBL24920105

SCHEMBL24920105

CC1SC(c2csc3cc(B4OC(C)(C)C(C)(C)O4)ccc23)=NC1=O

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 2/20 0.34
WDR77 Q9BQA1 2/20 0.34
CSF1R P07333 1/20 0.32
IDO1 P14902 1/20 0.32
TDO2 P48775 1/20 0.32
LPL P06858 3/20 0.32
LIPG Q9Y5X9 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24920106 0.80 PRMT5 (0.36) PRMT5WDR77CSF1RIDO1TDO2
SCHEMBL24920087 0.76 LIPG (0.46) LPLLIPG
SCHEMBL24920082 0.69 LPL (0.31) LPLLIPG
SCHEMBL24920073 0.68 SNCA (0.36) IDO1TDO2
SCHEMBL24920081 0.67
SCHEMBL27002489 0.66 CYP2A6 (0.40) CSF1RLPLLIPG
SCHEMBL29915023 0.66 CYP2A6 (0.40) CSF1RLPLLIPG
SCHEMBL2083540 0.66 PRMT5 (0.38) PRMT5WDR77CSF1RLPLLIPG
SCHEMBL29786772 0.65 LPL (0.46) CSF1RLPLLIPG
SCHEMBL8749259 0.65 LPL (0.46) CSF1RLPLLIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023004138-A1 AGONISTS OF TYRO3 AS PROTECTION AGAINST PODOCYTE INJURY IN KIDNEY GLOMERULAR DISEASE DAS BHASKAR (US) 2023-01-26 WO disclosed