Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 3/20 | 0.65 |
| ▸ | CTSL | P07711 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | APAF1 | O14727 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | CASP6 | P55212 | 1/20 | 0.64 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.64 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.64 |
| ▸ | FABP4 | P15090 | 3/20 | 0.59 |
| ▸ | FABP3 | P05413 | 2/20 | 0.59 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.59 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | CLCN2 | P51788 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953735 | 0.93 | CTSV (0.69) | CTSVCTSLKDM4EAPAF1RECQL | |
| SCHEMBL9952450 | 0.90 | KDM4E (0.77) | CTSVCTSLKDM4EAPAF1RECQL | |
| SCHEMBL1487895 | 0.82 | RAB9A (0.62) | HTTMEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL2595461 | 0.82 | HTT (0.63) | KDM4EHTTMEN1ALDH1A1KMT2A | |
| SCHEMBL7825169 | 0.81 | MEN1 (0.67) | CTSVCTSLKDM4EAPAF1RECQL | |
| SCHEMBL27621946 | 0.79 | FABP4 (0.58) | CTSVCTSLKDM4EAPAF1RECQL | |
| SCHEMBL1720516 | 0.78 | KDM4E (1.00) | CTSVCTSLKDM4EAPAF1RECQL | |
| SCHEMBL29441241 | 0.78 | KDM4E (1.00) | CTSVCTSLKDM4EAPAF1RECQL | |
| SCHEMBL22453646 | 0.77 | RECQL (0.61) | CTSVCTSLKDM4EAPAF1RECQL | |
| SCHEMBL1961759 | 0.77 | CTSV (0.62) | CTSVCTSLKDM4EAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |