SCHEMBL24925941

SCHEMBL24925941

Cc1cnc(-c2cc(C)c(C)cc2C)cc1C

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.44
NOS1 P29475 1/20 0.44
NOS2 P35228 1/20 0.44
LDHA P00338 1/20 0.35
ALDH1A1 P00352 3/20 0.33
MAPT P10636 2/20 0.33
MEN1 O00255 1/20 0.33
ALOX12 P18054 1/20 0.33
MAPK10 P53779 1/20 0.33
KMT2A Q03164 1/20 0.33
ATM Q13315 1/20 0.33
CCR1 P32246 1/20 0.32
CCR5 P51681 1/20 0.32
CCR8 P51685 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.32
NPC1 O15118 1/20 0.32
NQO2 P16083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19996635 0.82 LDHA (0.50) NOS3NOS1NOS2LDHAALDH1A1
SCHEMBL811129 0.82 NOS3 (0.55) NOS3NOS1NOS2LDHAALDH1A1
SCHEMBL29531822 0.82 NOS3 (0.55) NOS3NOS1NOS2LDHAALDH1A1
SCHEMBL25012097 0.81 LDHA (0.49) NOS3NOS1NOS2LDHAALDH1A1
SCHEMBL18808906 0.80 UHRF1 (0.43) NOS3NOS1NOS2LDHA
SCHEMBL5573554 0.79 NOS3 (0.52) NOS3NOS1NOS2LDHAALDH1A1
SCHEMBL28473855 0.79 NOS3 (0.52) NOS3NOS1NOS2LDHAALDH1A1
SCHEMBL24118192 0.79 CCR1 (0.41) NOS3NOS1NOS2ALDH1A1MAPT
SCHEMBL18730150 0.79 ALPL (0.42) NOS3NOS1NOS2LDHAALDH1A1
SCHEMBL16716059 0.76 CYP1A2 (0.51) NOS3NOS1NOS2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230322829-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-12 US disclosed
US-20230225184-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-07-13 US disclosed
US-20230157154-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-05-18 US disclosed
US-20230120996-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-04-20 US disclosed
US-20230029347-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230157154-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LIFR, SOD1, GLRA3 NOS3 876/4885NOS1 1646/4885NOS2 1831/4885
US-20230225184-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ESRRG, TECR, OXSR1 NOS3 731/4885NOS1 437/4885NOS2 415/4885
US-20230029347-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, OSBP NOS3 2104/4885NOS1 722/4885NOS2 1198/4885
US-20230322829-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, ICOSLG NOS3 1385/4885NOS1 982/4885NOS2 676/4885
US-20230120996-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ICOSLG, OCIAD2, OSBP NOS3 2166/4885NOS1 2423/4885NOS2 2256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.