Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.42 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28474744 | 0.79 | CA2 (0.48) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL483731 | 0.78 | TRPV6 (0.45) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL27914578 | 0.76 | ENPP2 (0.54) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL19712647 | 0.75 | ENPP2 (0.59) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL117688 | 0.75 | ENPP2 (0.43) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL14068806 | 0.71 | ENPP2 (0.54) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL27233293 | 0.70 | ENPP2 (0.52) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| Hydrochloric Acid SCHEMBL2319249 | 0.70 | ENPP2 (0.52) | ENPP2TRPV6ORAI1ORAI2ORAI3 | |
| SCHEMBL12615709 | 0.67 | CYP19A1 (0.30) | — | |
| SCHEMBL21449321 | 0.67 | ENPP2 (0.48) | ENPP2TRPV6ORAI1ORAI2ORAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379535-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | Array Biopharma Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010075200-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2010-07-01 | — | — | WO | disclosed |