Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 4/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644329 | 0.90 | CACNA2D1 (0.37) | CACNA2D1CACNA1BCACNB1CACNA1CCNR1 | |
| SCHEMBL2489242 | 0.86 | ICMT (0.35) | CNR1CNR2ICMTALBCCR5 | |
| SCHEMBL492596 | 0.84 | ALDH1A1 (0.37) | CACNA2D1CACNA1BCACNB1CACNA1CCNR1 | |
| SCHEMBL492975 | 0.83 | CACNA2D1 (0.37) | CACNA2D1CACNA1BCACNB1CACNA1CCNR1 | |
| SCHEMBL493117 | 0.77 | CACNA2D1 (0.42) | CACNA2D1CACNA1BCACNB1CACNA1CCCR5 | |
| SCHEMBL493013 | 0.77 | MEN1 (0.37) | CACNA2D1CACNA1BCACNB1CACNA1CCNR2 | |
| SCHEMBL492867 | 0.77 | BDKRB1 (0.39) | CACNA2D1CACNA1BCACNB1CACNA1CCNR1 | |
| SCHEMBL492976 | 0.76 | ALDH1A1 (0.37) | CACNA2D1CACNA1BCACNB1CACNA1CCNR1 | |
| SCHEMBL493688 | 0.76 | PTGIR (0.37) | CACNA2D1CACNA1BCACNB1CACNA1CRAB9A | |
| SCHEMBL493360 | 0.76 | LMNA (0.39) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | claimed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | claimed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |