Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493714 | 0.94 | CACNA2D1 (0.42) | BDKRB1L3MBTL1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL492975 | 0.94 | CACNA2D1 (0.37) | BDKRB1L3MBTL1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL492596 | 0.93 | ALDH1A1 (0.37) | BDKRB1L3MBTL1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL493326 | 0.93 | MEN1 (0.38) | BDKRB1L3MBTL1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL493360 | 0.90 | LMNA (0.39) | BDKRB1ALDH1A1TDP1GAASMN1; SMN2 | |
| SCHEMBL493804 | 0.89 | BDKRB1 (0.38) | BDKRB1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL493689 | 0.88 | CACNA2D1 (0.37) | BDKRB1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL493117 | 0.88 | CACNA2D1 (0.42) | BDKRB1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL493013 | 0.87 | MEN1 (0.37) | BDKRB1L3MBTL1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL493313 | 0.86 | BDKRB1 (0.53) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | BDKRB1 1622/4885L3MBTL1 4753/4885CACNA2D1 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.