Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334839 | 0.85 | GLP1R (0.31) | CYP11B1CYP11B2 | |
| SCHEMBL5021671 | 0.80 | CYP11B1 (0.33) | CYP11B1CYP11B2SLC22A12 | |
| SCHEMBL20489642 | 0.65 | ALDH1A1 (0.35) | HTTSMN1; SMN2MEN1KMT2ACYP11B1 | |
| SCHEMBL10179290 | 0.64 | EGLN1 (0.41) | — | |
| SCHEMBL10179150 | 0.64 | DDB1 (0.48) | SMN1; SMN2NPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL335593 | 0.63 | CHRNB2 (0.38) | RAB9ACYP11B1CYP11B2 | |
| SCHEMBL8542228 | 0.62 | — | — | |
| SCHEMBL8541963 | 0.62 | SMN1; SMN2 (0.37) | RAB9ASMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL1722652 | 0.62 | TDP1 (0.58) | HTTRAB9ASMN1; SMN2NPSR1MEN1 | |
| SCHEMBL8544532 | 0.60 | KDM4E (0.40) | HTTSMN1; SMN2NPSR1KMT2ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379554-A1 | NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010081874-A1 | NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |