Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | LATS1 | O95835 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29980148 | 1.00 | KDM4E (0.44) | KDM4ESMN1; SMN2TSHRPOLBRAB9A | |
| SCHEMBL10070999 | 0.83 | KDM4E (0.56) | KDM4ESMN1; SMN2RAB9AKMT2ACYP1A2 | |
| SCHEMBL29923388 | 0.82 | KDM4E (0.57) | KDM4ESMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL14740765 | 0.81 | KDM4E (0.48) | KDM4ESMN1; SMN2TSHRPOLBRAB9A | |
| SCHEMBL16215497 | 0.80 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2RAB9ANAPRTKMT2A | |
| SCHEMBL29873554 | 0.80 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2RAB9ANAPRTKMT2A | |
| SCHEMBL24971619 | 0.79 | TRPA1 (0.41) | KDM4ESMN1; SMN2TSHRPOLBRAB9A | |
| SCHEMBL23367108 | 0.77 | KDM4E (0.40) | KDM4EKMT2AMEN1 | |
| SCHEMBL23354039 | 0.77 | KDM4E (0.55) | KDM4ESMN1; SMN2TSHRPOLBRAB9A | |
| SCHEMBL17884923 | 0.77 | POLB (0.44) | KDM4ESMN1; SMN2TSHRPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230027346-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230027346-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | ADAMTS7, MMP7, ADAM17 | KDM4E 3062/4885SMN1; SMN2 3850/4885TSHR 1345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.