Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30240717 | 1.00 | CYP11B2 (0.38) | CYP11B2CYP11B1XDHPRMT5HSD17B1 | |
| SCHEMBL30240676 | 0.91 | PRMT5 (0.40) | CYP11B2CYP11B1PRMT5HSD17B1HSD17B2 | |
| SCHEMBL24933268 | 0.91 | PRMT5 (0.40) | CYP11B2CYP11B1PRMT5HSD17B1HSD17B2 | |
| SCHEMBL24933228 | 0.82 | CYP11B1 (0.37) | CYP11B2CYP11B1XDHHSD17B1HSD17B2 | |
| SCHEMBL30240736 | 0.81 | MKNK1 (0.44) | CYP11B2PRMT5 | |
| SCHEMBL24933267 | 0.81 | HSD17B1 (0.40) | HSD17B1HSD17B2 | |
| SCHEMBL24933394 | 0.81 | PARP15 (0.39) | CYP11B2HSD17B1HSD17B2MAPK1 | |
| SCHEMBL24933819 | 0.81 | PRKAB2 (0.40) | HSD17B1HSD17B2 | |
| SCHEMBL24933589 | 0.81 | XDH (0.49) | XDHHSD17B1HSD17B2 | |
| SCHEMBL24933810 | 0.81 | FFAR4 (0.40) | PRMT5HSD17B1HSD17B2FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |