SCHEMBL24934753

SCHEMBL24934753

CC(=O)COCCC(F)COc1c(F)cc(C)cc1F

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CCNT1 O60563 1/20 0.31
CCNB2 O95067 1/20 0.31
CCNE2 O96020 1/20 0.31
CDK1 P06493 1/20 0.31
CDK4 P11802 1/20 0.31
CCNB1 P14635 1/20 0.31
CCNA2 P20248 1/20 0.31
CCND1 P24385 1/20 0.31
CCNE1 P24864 1/20 0.31
CDK2 P24941 1/20 0.31
CCND2 P30279 1/20 0.31
CCND3 P30281 1/20 0.31
CDK7 P50613 1/20 0.31
CDK9 P50750 1/20 0.31
CCNH P51946 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24934755 0.84 MRGPRX4 (0.41) ALDH1A1HPGDCYP3A4
SCHEMBL24935188 0.82 ALDH1A1 (0.35) KDM4EALDH1A1HPGDMAPK1HSD17B10
SCHEMBL24935659 0.76 MRGPRX4 (0.44) ALDH1A1
SCHEMBL25063752 0.76 EIF4A3 (0.31)
SCHEMBL24935554 0.70 MEN1 (0.46) ALDH1A1HPGDMAPK1
SCHEMBL25063930 0.70 EIF4A3 (0.38) KDM4EALDH1A1CES2CYP3A4
SCHEMBL24934777 0.69 CCNT1 (0.37) KDM4EALDH1A1CCNT1CCNB2CCNE2
SCHEMBL24935230 0.66 MRGPRX4 (0.46)
SCHEMBL19019341 0.64 KDM4E (0.34) KDM4EALDH1A1
SCHEMBL22877078 0.64 THRA (0.42) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4119546-A1 BIFUNCTIONAL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF Suzhou Kintor Pharmaceuticals, Inc. (CN) 2023-01-18 EP disclosed