Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.54 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24945816 | 0.92 | ALOX15 (0.60) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL4126691 | 0.87 | ALOX15 (0.64) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL16117670 | 0.81 | ALDH1A1 (0.67) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL9503098 | 0.79 | ALDH1A1 (0.71) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL16736702 | 0.79 | ALOX15 (0.71) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL23239698 | 0.78 | RAPGEF4 (0.40) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL396943 | 0.76 | ALDH1A1 (0.54) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL16117675 | 0.75 | ALDH1A1 (0.58) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL10698070 | 0.75 | TMPRSS4 (0.39) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL16699742 | 0.75 | NOTUM (0.47) | CYP3A4TSHRTDP1MAPK1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026611-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026611-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNA3, KCNH2, KCNJ2 | ALDH1A1 1910/4885ALOX15 4647/4885SMN1; SMN2 2503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.