Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30202828 | 1.00 | JUN (0.41) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL30202952 | 0.85 | JUN (0.46) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL24951472 | 0.79 | NFKB1 (0.46) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL24952254 | 0.77 | RAB9A (0.47) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL22145716 | 0.76 | NPC1 (0.50) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL20558515 | 0.75 | NFKB1 (0.54) | JUNNFKB1NFKB2RELAMAPT | |
| SCHEMBL20558385 | 0.73 | RXFP1 (0.46) | JUNNFKB1NFKB2RELAPOLB | |
| SCHEMBL20558390 | 0.72 | XPO1 (0.58) | JUNNFKB1NFKB2RELANPC1 | |
| SCHEMBL4727523 | 0.71 | GAA (0.46) | MAPTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL22145719 | 0.71 | NFKB1 (0.48) | JUNNFKB1NFKB2RELAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |