Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 6/20 | 0.46 |
| ▸ | ATF1 | P18846 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30202682 | 0.88 | ALDH1A1 (0.46) | NFKB1ATF1ALDH1A1KDM4EMAPT | |
| SCHEMBL24951831 | 0.88 | ALDH1A1 (0.46) | NFKB1ATF1ALDH1A1KDM4EMAPT | |
| SCHEMBL30202783 | 0.86 | WDR5 (0.47) | NFKB1ATF1ALDH1A1KDM4EMAPT | |
| SCHEMBL24951146 | 0.86 | WDR5 (0.47) | NFKB1ATF1ALDH1A1KDM4EMAPT | |
| SCHEMBL30202755 | 0.86 | NFKB1 (0.50) | NFKB1ATF1ALDH1A1KDM4EJUN | |
| SCHEMBL24952216 | 0.86 | NFKB1 (0.50) | NFKB1ATF1ALDH1A1KDM4EJUN | |
| SCHEMBL30202828 | 0.79 | JUN (0.41) | NFKB1ALDH1A1KDM4EJUNNFKB2 | |
| SCHEMBL24951998 | 0.79 | JUN (0.41) | NFKB1ALDH1A1KDM4EJUNNFKB2 | |
| SCHEMBL30202695 | 0.75 | ALDH1A1 (0.40) | NFKB1ATF1ALDH1A1KDM4EJUN | |
| SCHEMBL24952254 | 0.75 | RAB9A (0.47) | NFKB1ALDH1A1KDM4EJUNNFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |