Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATF1 | P18846 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24951831 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KDM4EATF1NFKB1KMT2A | |
| SCHEMBL24951146 | 0.92 | WDR5 (0.47) | ALDH1A1KDM4EATF1NFKB1KMT2A | |
| SCHEMBL30202783 | 0.92 | WDR5 (0.47) | ALDH1A1KDM4EATF1NFKB1KMT2A | |
| SCHEMBL24951472 | 0.88 | NFKB1 (0.46) | ALDH1A1KDM4EATF1NFKB1RAB9A | |
| SCHEMBL24951630 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4EATF1NFKB1KMT2A | |
| SCHEMBL30202869 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4EATF1NFKB1KMT2A | |
| SCHEMBL24952254 | 0.83 | RAB9A (0.47) | ALDH1A1KDM4ENFKB1KMT2AMEN1 | |
| SCHEMBL22145716 | 0.78 | NPC1 (0.50) | ALDH1A1KDM4ENFKB1KMT2ARAB9A | |
| SCHEMBL24951126 | 0.77 | NFKB1 (0.50) | ALDH1A1KDM4EATF1NFKB1KMT2A | |
| SCHEMBL30202837 | 0.77 | NFKB1 (0.50) | ALDH1A1KDM4EATF1NFKB1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4376845-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |