Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.46 |
| ▸ | P2RX2 | Q9UBL9 | 4/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22448800 | 0.85 | P2RX3 (0.40) | SIRT6P2RX3P2RX2POLBGAA | |
| SCHEMBL23047437 | 0.81 | TRPC6 (0.55) | SIRT6P2RX3P2RX2PDE4APDE4B | |
| SCHEMBL24960091 | 0.81 | HPGDS (0.42) | P2RX3P2RX2MAPK1TSHRMEN1 | |
| SCHEMBL1673227 | 0.78 | TSHR (0.50) | SIRT6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22448707 | 0.77 | LCK (0.46) | SIRT6P2RX3P2RX2TSHRALDH1A1 | |
| SCHEMBL24959354 | 0.77 | SIRT6 (0.49) | SIRT6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22448804 | 0.77 | P2RX3 (0.39) | P2RX3P2RX2POLBGAAGFER | |
| SCHEMBL22439412 | 0.76 | P2RX3 (0.67) | P2RX3P2RX2 | |
| SCHEMBL29839611 | 0.76 | P2RX3 (0.67) | P2RX3P2RX2 | |
| SCHEMBL24960105 | 0.75 | SIRT6 (0.47) | SIRT6PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230021705-A1 | GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230021705-A1 | GLP-1R MODULATING COMPOUNDS | GLP1R, GIPR, GPR119 | SIRT6 764/4885P2RX3 177/4885P2RX2 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.