SCHEMBL24974637

SCHEMBL24974637

CCCn1cc(-c2ccc(NC(=O)C3CC(=O)N(c4cc(F)ccc4F)C3)cc2)nn1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.48
▸ MEN1 O00255 4/20 0.48
▸ ATM Q13315 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ KDR P35968 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ RXFP1 Q9HBX9 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ POLB P06746 2/20 0.40
▸ CLK1 P49759 1/20 0.40
▸ ROCK2 O75116 1/20 0.40
▸ ROCK1 Q13464 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21152067 0.84 POLB (0.47) KMT2AKDRGAAALDH1A1SMN1; SMN2
SCHEMBL24974634 0.84 POLB (0.56) ALDH1A1SMN1; SMN2MAPTPOLB
SCHEMBL24974601 0.83 ROCK2 (0.54) KMT2AMEN1L3MBTL1GAAALDH1A1
SCHEMBL24974782 0.81 MAPT (0.58) KMT2AMEN1GAAALDH1A1SMN1; SMN2
SCHEMBL24974742 0.81 MAPT (0.58) KMT2AMEN1KDM4EALDH1A1MAPT
SCHEMBL24974638 0.77 PKM (0.47) KDR
SCHEMBL24974541 0.75 ALDH1A1 (0.52) L3MBTL1KDRALDH1A1SMN1; SMN2POLB
SCHEMBL24974592 0.75 ALDH1A1 (0.46) KDRALDH1A1SMN1; SMN2MAPTPOLB
SCHEMBL24974737 0.69 HDAC1 (0.42) KMT2AKDRALDH1A1MAPTPOLB
SCHEMBL24974573 0.69 HDAC1 (0.42) KMT2AKDRALDH1A1MAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11572370-B2 CD16A binding agents and uses thereof BIOHAVEN THERAPEUTICS LTD. (US) 2023-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572370-B2 CD16A binding agents and uses thereof FCGR1A, FCGR2A, FCGR3B KMT2A 499/4885MEN1 2237/4885ATM 4190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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