SCHEMBL2497519

SCHEMBL2497519

Fc1cc(F)cc(N2c3ccccc3Sc3ccccc32)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
BCHE P06276 5/20 0.41
NOX1 Q9Y5S8 4/20 0.39
ACHE P22303 2/20 0.39
MEN1 O00255 1/20 0.39
ADRA2A P08913 1/20 0.39
ADRA2B P18089 1/20 0.39
ADRA2C P18825 1/20 0.39
CHRM3 P20309 1/20 0.39
SLC6A2 P23975 1/20 0.39
HTR2C P28335 1/20 0.39
SLC6A4 P31645 1/20 0.39
DRD3 P35462 1/20 0.39
HTR2B P41595 1/20 0.39
KMT2A Q03164 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
LMNA P02545 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18365088 0.89 MAOA (0.38) MAOAHDAC6BCHENOX1ACHE
SCHEMBL12190857 0.86 MAOA (0.54) MAOAHDAC6BCHENOX1ACHE
SCHEMBL28595448 0.82 HDAC6 (0.54) MAOAHDAC6BCHENOX1ACHE
SCHEMBL29851224 0.79 HDAC6 (0.62) MAOAHDAC6BCHENOX1ACHE
SCHEMBL12190901 0.79 HDAC6 (0.62) MAOAHDAC6BCHENOX1ACHE
SCHEMBL12190894 0.78 MAOA (0.50) MAOAHDAC6BCHENOX1ACHE
SCHEMBL342426 0.77 HDAC6 (0.56) MAOAHDAC6BCHENOX1ACHE
SCHEMBL29387100 0.77 HDAC6 (0.56) MAOAHDAC6BCHENOX1ACHE
SCHEMBL12349411 0.77 HDAC6 (0.49) MAOAHDAC6BCHENOX1ACHE
SCHEMBL17370164 0.77 HDAC6 (0.49) MAOAHDAC6BCHENOX1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1817806-B1 PHENOTHAZINES-S-OXIDES AND S,S-DIOXIDES AS hole and excitonblockers for OLEDs BASF SE (DE) 2014-07-30 EP disclosed
EP-1817806-B1 PHENOTHAZINES-S-OXIDES AND S,S-DIOXIDES AS hole and excitonblockers for OLEDs BASF SE (DE) 2014-07-30 EP disclosed
US-8029919-B2 Phenothiazines, S-oxides, and S,S-dioxides as well as phenoxazines as emitters for OLEDs BASF AKTIENGESELLSCHAFT (DE) 2011-10-04 US disclosed
US-8029919-B2 Phenothiazines, S-oxides, and S,S-dioxides as well as phenoxazines as emitters for OLEDs BASF AKTIENGESELLSCHAFT (DE) 2011-10-04 US disclosed
US-8029919-B2 Phenothiazines, S-oxides, and S,S-dioxides as well as phenoxazines as emitters for OLEDs BASF AKTIENGESELLSCHAFT (DE) 2011-10-04 US disclosed
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds BASF AKTIENGESELLSCHAFT (DE) 2010-12-09 US disclosed
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds BASF AKTIENGESELLSCHAFT (DE) 2010-12-09 US disclosed
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds BASF AKTIENGESELLSCHAFT (DE) 2010-12-09 US disclosed
US-20080018238-A1 Use Of Phenothiazine-S-Oxides And Phenothiazine -S,S-Dioxides In The Form Of Matrix Materials For Organic Light-Emitting Diodes BASF AKTIENGESELLSCHAFT (DE) 2008-01-24 US disclosed
US-20080018238-A1 Use Of Phenothiazine-S-Oxides And Phenothiazine -S,S-Dioxides In The Form Of Matrix Materials For Organic Light-Emitting Diodes BASF AKTIENGESELLSCHAFT (DE) 2008-01-24 US disclosed
US-20080018238-A1 Use Of Phenothiazine-S-Oxides And Phenothiazine -S,S-Dioxides In The Form Of Matrix Materials For Organic Light-Emitting Diodes BASF AKTIENGESELLSCHAFT (DE) 2008-01-24 US disclosed
EP-1817805-A1 USE OF PHENOTHIAZINE-S-OXIDES AND PHENOTHIAZINE -S,S-DIOXIDES IN THE FORM OF MATRIX MATERIALS FOR ORGANIC LIGHT-EMITTING DIODES BASF AKTIENGESELLSCHAFT (DE) 2007-08-15 EP disclosed
EP-1817806-A1 PHENOTHAZINES, -S-OXIDES, AND S,S-DIOXIDES AS WELL AS PHENOXAZINES AS EMITTERS FOR OLEDS BASF AKTIENGESELLSCHAFT (DE) 2007-08-15 EP disclosed
WO-2006056465-A1 PHENOTHIAZINES, -S-OXIDES, AND S,S-DIOXIDES AS WELL AS PHENOXAZINES AS EMITTERS FOR OLEDS BASF AKTIENGESELLSCHAFT (DE) 2006-06-01 WO disclosed
WO-2006056416-A1 USE OF PHENOTHIAZINE-S-OXIDES AND PHENOTHIAZINE -S,S-DIOXIDES IN THE FORM OF MATRIX MATERIALS FOR ORGANIC LIGHT-EMITTING DIODES BASF AKTIENGESELLSCHAFT (DE) 2006-06-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100308714-A1 Phenothiazines, S-Oxides, And S,S-Dioxides As Well As Phenoxazines As Emitters For Oleds PPOX, SMOX, SORD MAOA 82/4885HDAC6 2567/4885BCHE 3606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.