Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 8/20 | 0.52 |
| ▸ | FDPS | P14324 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25003144 | 0.84 | KMO (0.51) | KMOFDPSNPC1ALDH1A1LMNA | |
| SCHEMBL25002894 | 0.82 | KMT2A (0.56) | KMONPC1ALDH1A1LMNARAB9A | |
| SCHEMBL25003934 | 0.81 | KDM4E (0.52) | FDPSPDE4DNPC1ALDH1A1LMNA | |
| SCHEMBL25003564 | 0.78 | NPC1 (0.55) | KMONPC1ALDH1A1LMNARAB9A | |
| SCHEMBL25002923 | 0.78 | FDPS (0.44) | FDPSPDE4DNPC1ALDH1A1LMNA | |
| SCHEMBL25002908 | 0.78 | FDPS (0.57) | FDPSPDE4DNPC1ALDH1A1LMNA | |
| SCHEMBL27237475 | 0.77 | ALDH1A1 (0.50) | KMOALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL30862201 | 0.77 | ALDH1A1 (0.50) | KMOALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL25003565 | 0.77 | KMO (0.50) | KMOFDPSNPC1ALDH1A1LMNA | |
| SCHEMBL25003570 | 0.77 | KMO (0.50) | KMONPC1ALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |