SCHEMBL2500361

SCHEMBL2500361

CCOC(OCC)C(=O)Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PREP P48147 4/20 0.39
DRD2 P14416 1/20 0.39
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA9 Q16790 2/20 0.36
PPARA Q07869 4/20 0.35
PPARG P37231 1/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12170755 0.89 PREP (0.38) PREPDRD2CA12CA1CA9
SCHEMBL16768167 0.89 PREP (0.38) PREPDRD2CA12CA1CA9
SCHEMBL22263572 0.89 PREP (0.44) PREPDRD2CA12CA1CA9
SCHEMBL559379 0.84 DRD2 (0.39) DRD2CA12CA1CA9PPARA
SCHEMBL2506528 0.81 SRD5A2 (0.46) PREPCA12CA1CA9POLB
SCHEMBL5281699 0.79 POLB (0.51) PREPDRD2CA12CA1CA9
SCHEMBL2507099 0.78 PREP (0.43) PREPDRD2CA12CA1CA9
SCHEMBL559283 0.77 HTT (0.54) POLB
SCHEMBL3839217 0.77 CYP4F2 (0.50) PREPDRD2
SCHEMBL12188771 0.76 BLM (0.33) PPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US claimed
US-11939332-B2 Synthesis of coelenterazine INTERNATIONAL PAPER COMPANY (US) 2024-03-26 US claimed
EP-3830088-A1 SYNTHESIS OF COELENTERAZINE International Paper Company (US) 2021-06-09 EP claimed
US-20210070762-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY (US) 2021-03-11 US claimed
CN-112368286-A Synthesis of coelenterazine 国际纸业公司 2021-02-12 CN claimed
US-20260016473-A1 REAGENT FOR DETECTING SARS-RELATED CORONAVIRUS AIST (JP) 2026-01-15 US disclosed
WO-2025084165-A1 METHOD FOR EVALUATING DENATURED STATE OF ANTIBODY 国立研究開発法人産業技術総合研究所 2025-04-24 WO disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 US disclosed
EP-4344689-A2 SYNTHESIS OF COELENTERAZINE International Paper Company (US) 2024-04-03 EP disclosed
US-11939332-B2 Synthesis of coelenterazine INTERNATIONAL PAPER COMPANY (US) 2024-03-26 US disclosed
US-8883432-B2 Coelenterazine analogues and coelenteramide analogues JNC CORPORATION (JP) 2014-11-11 US disclosed
US-20140316137-A1 COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES JNC CORP (JP) 2014-10-23 US disclosed
US-20140206868-A1 PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2014-07-24 US disclosed
US-8772484-B2 Process for producing benzo[f]quinoxaline compounds JNC CORPORATION (JP) 2014-07-08 US disclosed
US-20140120538-A1 COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2014-05-01 US disclosed
US-8642281-B2 Coelenterazine analogues and coelenteramide analogues JNC CORPORATION (JP) 2014-02-04 US disclosed
US-20120232272-A1 PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2012-09-13 US disclosed
US-20110244481-A1 COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES JNC CORPORATION (JP) 2011-10-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140120538-A1 COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES CCKAR, SI, GLP1R PREP 372/4885DRD2 2537/4885CA12 131/4885
US-11939332-B2 Synthesis of coelenterazine ACHE, UROD, DDT PREP 133/4885DRD2 1432/4885CA12 1056/4885
US-20140206868-A1 PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS F5, METAP2, MTX2 PREP 315/4885DRD2 732/4885CA12 636/4885
US-20140316137-A1 COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES CCKAR, SI, GLP1R PREP 437/4885DRD2 2637/4885CA12 266/4885
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE ACHE, UROD, DDT PREP 133/4885DRD2 1432/4885CA12 1056/4885
US-20210070762-A1 SYNTHESIS OF COELENTERAZINE ACHE, UROD, DDT PREP 133/4885DRD2 1432/4885CA12 1056/4885
US-20120232272-A1 PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS F5, METAP2, MTX2 PREP 315/4885DRD2 732/4885CA12 636/4885
US-20110244481-A1 COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES CCKAR, SI, GLP1R PREP 372/4885DRD2 2537/4885CA12 131/4885
US-20260016473-A1 REAGENT FOR DETECTING SARS-RELATED CORONAVIRUS SARS1, CYP2F1, CYP7A1 PREP 1566/4885DRD2 1667/4885CA12 2039/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.