Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933140 | 0.82 | CRHR1 (0.38) | CRHR1GRM8CYP1A2GRM7 | |
| SCHEMBL2492930 | 0.80 | PIK3CG (0.38) | — | |
| SCHEMBL3926033 | 0.72 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL2930712 | 0.68 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL2498882 | 0.68 | POLB (0.39) | CRHR1GRM8CYP1A2GRM7 | |
| SCHEMBL2495462 | 0.67 | KDM4E (0.38) | CRHR1GRM8CYP1A2GRM7 | |
| SCHEMBL2929183 | 0.67 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL2932988 | 0.67 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL3146714 | 0.66 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL3935803 | 0.65 | CRHR1 (0.51) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030304-B2 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | ELI LILLY AND COMPANY (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100222339-A1 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | ELI LILLY AND COMPANY | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222339-A1 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | CRHR1, CRH, CRHR2 | CRHR1 1/4885GRM8 173/4885CYP1A2 1668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.