SCHEMBL25008724

SCHEMBL25008724

COCc1cc(-c2nc3c(C)cc(Cl)cc3c(=O)o2)n(-c2ncccc2Cl)n1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ SLC16A3 O15427 9/20 0.34
▸ SLC16A1 P53985 7/20 0.34
▸ DHODH Q02127 2/20 0.32
▸ KLK7 P49862 1/20 0.32
▸ KLK14 Q9P0G3 1/20 0.32
▸ KLK5 Q9Y337 1/20 0.32
▸ CYP17A1 P05093 1/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ MAPT P10636 2/20 0.31
▸ NPSR1 Q6W5P4 2/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ HTT P42858 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.30
▸ POLB P06746 1/20 0.30
▸ MCTS1 Q9ULC4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31060065 0.90 DHODH (0.33) SLC16A3SLC16A1DHODHCYP17A1CYP1A2
SCHEMBL25008237 0.90 OPRL1 (0.34) SLC16A3SLC16A1DHODHKLK7KLK14
SCHEMBL12529033 0.90 DHODH (0.32) DHODHCYP17A1CYP1A2MAPTNPSR1
SCHEMBL31060017 0.89 PTGS1 (0.35) SLC16A3SLC16A1CYP1A2MAPTNPSR1
SCHEMBL30233941 0.88 DHODH (0.32) DHODHCYP17A1CYP1A2MAPTNPSR1
SCHEMBL29215191 0.88 DHODH (0.32) DHODHCYP17A1CYP1A2MAPTNPSR1
SCHEMBL25008097 0.87 PTGS2 (0.32) DHODHCYP17A1CYP1A2MAPTNPSR1
SCHEMBL950938 0.86 CYP17A1 (0.34) DHODHCYP17A1CYP1A2MAPTNPSR1
SCHEMBL1762432 0.86 CYP17A1 (0.34) DHODHCYP17A1CYP1A2MAPTNPSR1
SCHEMBL12856449 0.85 DHODH (0.33) DHODHCYP17A1CYP1A2MAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240308988-A1 Method For Controlling Diamide Resistant Pests and Compounds Therefor SYNGENTA CROP PROTECTION AG (CH) 2024-09-19 — — US disclosed
EP-4380363-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR Syngenta Crop Protection AG (CH) 2024-06-12 — — EP disclosed
CN-118076228-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-05-24 — — CN disclosed
WO-2023012081-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR SYNGENTA CROP PROTECTION AG (CH) 2023-02-09 — — WO disclosed
WO-2023012081-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR SYNGENTA CROP PROTECTION AG (CH) 2023-02-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240308988-A1 Method For Controlling Diamide Resistant Pests and Compounds Therefor DDT, NOS1, SLC11A2 SLC16A3 1408/4885SLC16A1 550/4885DHODH 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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