Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27641457 | 0.86 | ADRB2 (0.43) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL4756232 | 0.85 | TP53 (0.38) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL4756193 | 0.84 | LMNA (0.36) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL6884986 | 0.84 | TP53 (0.37) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL3398321 | 0.84 | USP2 (0.37) | LMNACYP1A2APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL1563267 | 0.84 | USP2 (0.37) | LMNACYP1A2APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL4697046 | 0.82 | LMNA (0.41) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL5147376 | 0.81 | CYP2D6 (0.36) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL3182386 | 0.81 | SMN1; SMN2 (0.35) | LMNACYP1A2APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL27622479 | 0.79 | CYP2D6 (0.40) | LMNACYP1A2CYP2D6SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902714-B1 | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2008157408-A2 | USE OF PRODRUGS OF GABA ANALOGS, ANTISPASTICITY AGENTS, AND PRODRUGS OF GABA B RECEPTOR AGONISTS FOR TREATING SPASTICITY | XENOPORT, INC. (US) | 2008-12-24 | — | — | WO | disclosed |