Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563323 | 0.87 | APOBEC3A (0.39) | TSHRLMNAKMT2AMEN1POLB | |
| SCHEMBL25013 | 0.85 | LMNA (0.41) | TP53TSHRSLC6A4SLC6A3CYP1A2 | |
| SCHEMBL6884986 | 0.83 | TP53 (0.37) | TP53TSHRSLC6A4SLC6A3CYP1A2 | |
| SCHEMBL4756193 | 0.81 | LMNA (0.36) | TP53TSHRSLC6A4SLC6A3CYP1A2 | |
| SCHEMBL28755061 | 0.81 | GABBR2 (0.36) | CYP1A2LMNAKMT2AMAPK1POLB | |
| SCHEMBL27641457 | 0.81 | ADRB2 (0.43) | TSHRSLC6A4SLC6A3CYP1A2LMNA | |
| SCHEMBL5147376 | 0.78 | CYP2D6 (0.36) | TP53TSHRSLC6A4SLC6A3CYP1A2 | |
| SCHEMBL25331 | 0.76 | GAA (0.39) | TP53TSHRSLC6A4SLC6A3CYP1A2 | |
| SCHEMBL27910096 | 0.74 | NPSR1 (0.43) | SLC6A4SLC6A3CYP1A2LMNASLC6A2 | |
| SCHEMBL27622479 | 0.74 | CYP2D6 (0.40) | TSHRSLC6A4SLC6A3CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101434572-B | Prodrugs of GABA analogs, compositions and uses thereof | XENOPORT INC | 2013-03-13 | — | — | CN | disclosed |
| CN-101381339-B | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC | 2012-03-07 | — | — | CN | disclosed |
| CN-1753673-B | Prodrugs of GABA analogs, compositions and uses thereof | XENOPORT INC | 2010-09-29 | — | — | CN | disclosed |
| CN-101434572-A | Prodrugs of GABA analogs, compositions and uses thereof | XENOPORT INC (US) | 2009-05-20 | — | — | CN | disclosed |
| CN-101381339-A | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2009-03-11 | — | — | CN | disclosed |
| WO-2008157408-A2 | USE OF PRODRUGS OF GABA ANALOGS, ANTISPASTICITY AGENTS, AND PRODRUGS OF GABA B RECEPTOR AGONISTS FOR TREATING SPASTICITY | XENOPORT, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1569895-A4 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT INC (US) | 2007-07-11 | — | — | EP | disclosed |
| CN-1753673-A | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2006-03-29 | — | — | CN | disclosed |
| EP-1569895-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | Xenoport, Inc. (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052844-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2004-06-24 | — | — | WO | disclosed |