SCHEMBL250139

SCHEMBL250139

O=C(O)CNCc1c[nH]c2ccccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MC1R Q01726 4/20 0.60
MC5R P33032 3/20 0.60
MC3R P41968 2/20 0.60
KDM4E B2RXH2 4/20 0.57
MAPT P10636 4/20 0.56
MEN1 O00255 4/20 0.56
KMT2A Q03164 4/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
ALDH1A1 P00352 1/20 0.56
HPGD P15428 1/20 0.56
SSTR3 P32745 1/20 0.54
SLC6A2 P23975 1/20 0.54
FNTA P49354 1/20 0.54
FNTB P49356 1/20 0.54
HDAC3 O15379 1/20 0.53
HDAC4 P56524 1/20 0.53
HDAC1 Q13547 1/20 0.53
HDAC7 Q8WUI4 1/20 0.53
HDAC2 Q92769 1/20 0.53
HDAC10 Q969S8 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29874992 1.00 MC1R (0.60) MC1RMC5RMC3RKDM4EMAPT
SCHEMBL26292984 0.86 MC1R (0.59) MC1RMC5RMC3RKDM4EMAPT
SCHEMBL29489675 0.85 MC5R (0.66) MC1RMC5RMC3RKDM4EMAPT
SCHEMBL660463 0.85 MC5R (0.66) MC1RMC5RMC3RKDM4EMAPT
SCHEMBL468296 0.82 LMNA (0.65) KDM4EMAPTMEN1KMT2ASMN1; SMN2
SCHEMBL29411993 0.82 LMNA (0.65) KDM4EMAPTMEN1KMT2ASMN1; SMN2
SCHEMBL4079184 0.81 MGAM (0.53) MC1RMC5RMC3RMAPTMEN1
SCHEMBL11568830 0.80 MC1R (0.59) MC1RMC5RMC3RKDM4EMAPT
SCHEMBL31370294 0.80 GLS (0.46) MC1RMC5RMC3RKDM4EMAPT
Indolylpropionic Acid SCHEMBL29374161 0.79 MAPT (0.68) KDM4EMAPTMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1569 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080233137-A1 Compounds that Block the C5a Receptor and Their Use in Therapy ALLIGATOR BIOSCIENCE AB (SE) 2008-09-25 US claimed
US-7256172-B1 Method of treatment and agents useful for same THE UNIVERSITY OF MELBOURNE (AU) 2007-08-14 US claimed
CN-1997664-A Compounds that block the C5A receptor and their use in therapy ALLIGATOR BIOSCIENCE AB PUBL (SE) 2007-07-11 CN claimed
EP-1737886-A2 COMPOUNDS THAT BLOCK THE C5A RECEPTOR AND THEIR USE IN THERAPY Alligator Bioscience AB (publ) (SE) 2007-01-03 EP claimed
WO-2005100385-A2 COMPOUNDS THAT BLOCK THE C5A RECEPTOR AND THEIR USE IN THERAPY ALLIGATOR BIOSCIENCE AB (PUBL) (SE) 2005-10-27 WO claimed
EP-1586583-A2 Compounds that block C5a complement receptor and their use in therapy Alligator Bioscience AB (publ) (SE) 2005-10-19 EP claimed
WO-2003006048-A1 COMBINATION OF CHIPS (CHEMOTAXIS INHIBITING PROTEIN FROM STAPHYLOCOCCUS AUREUS)-BASED COMPOUNDS JARI PHARMACEUTICALS B.V. (NL) 2003-01-23 WO claimed
WO-2024118635-A2 THERMOSTABLE BINDING SCAFFOLDS NECTAGEN, INC. (US) 2024-06-06 WO disclosed
US-20240182532-A1 MICROPEPTIDES AND USES THEREOF FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÒGICA DE VALL HEBRON (ES) 2024-06-06 US disclosed
US-20240174730-A1 VARIANT FC DOMAINS AND USES THEREOF CIDARA THERAPEUTICS, INC. 2024-05-30 US disclosed
US-11986522-B2 Immunotherapeutic composition and uses thereof ARA VAX PTY LTD (AU) 2024-05-21 US disclosed
US-20240156975-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS CIDARA THERAPEUTICS, INC. 2024-05-16 US disclosed
US-11980658-B2 Immunotherapeutic molecules and uses thereof ARAVAX PTY LTD (AU) 2024-05-14 US disclosed
WO-1997023629-A1 A NOVEL RECEPTOR-TYPE TYROSINE KINASE AND USE THEREOF AMRAD OPERATIONS PTY. LTD. (AU) 1997-07-03 WO disclosed
WO-1997023501-A1 THERAPEUTIC COMPOSITIONS AMRAD OPERATIONS PTY. LTD. (AU) 1997-07-03 WO disclosed
WO-1997021727-A1 MYCOPLASMA RECOMBINANT POLYPEPTIDE VACCINES THE UNIVERSITY OF MELBOURNE (AU) 1997-06-19 WO disclosed
WO-1997016202-A1 CYTOKINES AND THEIR USE IN TREATMENT AND/OR PROPHYLAXIS OF BREAST CANCER AMRAD OPERATIONS PTY. LTD. (AU) 1997-05-09 WO disclosed
WO-1997015663-A1 A NOVEL HAEMOPOIETIN RECEPTOR AND GENETIC SEQUENCES ENCODING SAME AMRAD OPERATIONS PTY. LTD. (AU) 1997-05-01 WO disclosed
WO-1997012037-A1 A NOVEL HAEMOPOIETIN RECEPTOR AND GENETIC SEQUENCES ENCODING SAME AMRAD OPERATIONS PTY. LTD. (AU) 1997-04-03 WO disclosed
WO-1997004091-A1 NOVEL RECEPTOR LIGANDS AND GENETIC SEQUENCES ENCODING SAME AMRAD OPERATIONS PTY. LTD. (AU) 1997-02-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240174730-A1 VARIANT FC DOMAINS AND USES THEREOF FCGR3B, FCGRT, FCGR2A MC1R 3614/4885MC5R 3026/4885MC3R 3386/4885
US-20240156975-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS FCGR3B, ALB, FCGR1A MC1R 4399/4885MC5R 4137/4885MC3R 3786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.