SCHEMBL250159

SCHEMBL250159

Cc1c(C=O)c2c(I)cccc2n1C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
CNR1 P21554 2/20 0.34
CNR2 P34972 2/20 0.34
ALDH1A1 P00352 6/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
LMNA P02545 3/20 0.34
POLB P06746 3/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
THRB P10828 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33
USP2 O75604 1/20 0.33
APEX1 P27695 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL249020 0.78 HTT (0.37) HTTSMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL251571 0.75 HTT (0.33) HTTSMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL28246281 0.68 ALDH1A1 (0.35) HTTCNR2ALDH1A1MEN1KMT2A
SCHEMBL249819 0.67 ALDH1A1 (0.33) CNR1CNR2ALDH1A1MEN1KMT2A
SCHEMBL16009974 0.65 POLB (0.48) HTTCNR1CNR2ALDH1A1MEN1
SCHEMBL28492551 0.63 KMT2A (0.39) HTTSMN1; SMN2CNR1CNR2ALDH1A1
SCHEMBL6902686 0.62 ALDH1A1 (0.48) ALDH1A1MEN1KMT2ALMNATHRB
SCHEMBL28360523 0.62 ALDH1A1 (0.43) ALDH1A1MEN1KMT2ALMNANPSR1
SCHEMBL9089305 0.62 CNR2 (0.54) HTTCNR1CNR2ALDH1A1MEN1
SCHEMBL22541883 0.61 MEN1 (0.35) HTTMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012001308-A9 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-03-22 WO disclosed
WO-2012001308-A1 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-01-05 WO disclosed