SCHEMBL25029253

SCHEMBL25029253

N#Cc1cccc2c(-c3ccc(OC4CCNC4)c(F)c3)c[nH]c12

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ BCL9 O00512 12/20 0.46
▸ CTNNB1 P35222 12/20 0.46
▸ GSK3B P49841 1/20 0.44
▸ DYRK1A Q13627 1/20 0.44
▸ TBK1 Q9UHD2 3/20 0.41
▸ CCNT1 O60563 1/20 0.40
▸ CCNK O75909 1/20 0.40
▸ CCNE1 P24864 1/20 0.40
▸ CDK2 P24941 1/20 0.40
▸ CDK9 P50750 1/20 0.40
▸ CDK12 Q9NYV4 1/20 0.40
▸ NR3C1 P04150 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL29005526 0.95 BCL9 (0.46) BCL9CTNNB1GSK3BDYRK1ATBK1
Formic Acid SCHEMBL29361291 0.95 BCL9 (0.46) BCL9CTNNB1GSK3BDYRK1ATBK1
SCHEMBL29364049 0.89 GSK3B (0.44) BCL9CTNNB1GSK3BDYRK1ATBK1
SCHEMBL25029333 0.89 GSK3B (0.44) BCL9CTNNB1GSK3BDYRK1ATBK1
SCHEMBL29363789 0.85 HTR1A (0.47) BCL9CTNNB1DYRK1ANR3C1
SCHEMBL25029276 0.85 HTR1A (0.47) BCL9CTNNB1DYRK1ANR3C1
SCHEMBL26180176 0.83 GSK3B (0.47) BCL9CTNNB1GSK3BDYRK1ATBK1
SCHEMBL25029240 0.79 GSK3B (0.47) GSK3BDYRK1ATBK1CCNT1CCNK
SCHEMBL25029015 0.79 GSK3B (0.47) GSK3BDYRK1ATBK1CCNT1CCNK
SCHEMBL29362012 0.79 GSK3B (0.47) GSK3BDYRK1ATBK1CCNT1CCNK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2023-11-02 — — US disclosed
CN-115996926-A Indole compounds as androgen receptor modulators 尼多生物科学有限公司 2023-04-21 — — CN disclosed
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 BCL9 2833/4885CTNNB1 1825/4885GSK3B 463/4885
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 BCL9 2836/4885CTNNB1 1679/4885GSK3B 441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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