Sugi Predict

Sugi Predict / Compounds / SCHEMBL25035120

SCHEMBL25035120

SCHEMBL25035120

NC1CCN(C(=O)CCN2CCN(c3cnn(C4CCC(=O)NC4=O)c3)CC2)CC1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HTR7 P34969 7/20 0.39
▸ HTR1A P08908 6/20 0.39
▸ CRBN Q96SW2 6/20 0.37
▸ DDB1 Q16531 3/20 0.37
▸ IRAK1 P51617 2/20 0.36
▸ IRAK4 Q9NWZ3 2/20 0.36
▸ IRAK3 Q9Y616 2/20 0.36
▸ CCNC P24863 1/20 0.36
▸ CDK8 P49336 1/20 0.36
▸ NTRK3 Q16288 1/20 0.36
▸ HASPIN Q8TF76 1/20 0.36
▸ CDK19 Q9BWU1 1/20 0.36
▸ ADAMTS5 Q9UNA0 3/20 0.34
▸ IKZF3 Q9UKT9 1/20 0.34
▸ ADAMTS4 O75173 2/20 0.33
▸ ADAM10 O14672 1/20 0.33
▸ MMP12 P39900 1/20 0.33
▸ ADAM17 P78536 1/20 0.33
▸ ADAM9 Q13443 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25819561 0.83 CRBN (0.42) CRBNDDB1IRAK1IRAK4IRAK3
SCHEMBL25935502 0.79 BRD9 (0.34) CRBNDDB1IKZF3
SCHEMBL25942080 0.79 BRD9 (0.34) CRBNDDB1IKZF3
SCHEMBL30938263 0.78 CRBN (0.62) CRBNDDB1IRAK1IRAK4IRAK3
SCHEMBL26814219 0.78 CRBN (0.62) CRBNDDB1IRAK1IRAK4IRAK3
SCHEMBL25031287 0.77 HTR7 (0.46) HTR7HTR1ACRBNDDB1ADAMTS5
SCHEMBL29260100 0.76 CRBN (0.52) CRBNDDB1IKZF3
SCHEMBL29179852 0.76 DDB1 (0.57) HTR7HTR1ACRBNDDB1ADAMTS5
SCHEMBL25035481 0.75 HTR7 (0.41) HTR7HTR1ACRBNDDB1IRAK1
SCHEMBL25035204 0.75 HTR7 (0.50) HTR7HTR1ACRBNDDB1ADAMTS5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116322700-B Novel PLK1 degradation inducing compounds 厄普特拉株式会社 2024-08-20 — — CN disclosed
US-11912710-B2 Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers UPPTHERA, INC. (KR) 2024-02-27 — — US disclosed
US-11912710-B2 Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers UPPTHERA, INC. (KR) 2024-02-27 — — US disclosed
US-20230219966-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-07-13 — — US disclosed
US-20230219966-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-07-13 — — US disclosed
CN-116322700-A Novel PLK1 degradation inducing compounds 厄普特拉株式会社 2023-06-23 — — CN disclosed
WO-2023017446-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-02-16 — — WO disclosed
WO-2023018238-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND UPPTHERA, INC. (KR) 2023-02-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219966-A1 NOVEL PLK1 DEGRADATION INDUCING COMPOUND PLK1, BUB1B, BUB1 HTR7 4012/4885HTR1A 4156/4885CRBN 2136/4885
US-11912710-B2 Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers PLK1, BUB1B, BUB1 HTR7 2918/4885HTR1A 2866/4885CRBN 2496/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.