Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.41 |
| ▸ | HTR1A | P08908 | 7/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25256962 | 0.88 | HTR7 (0.39) | HTR7HTR1ACRBNDDB1CCNC | |
| SCHEMBL25825148 | 0.86 | CRBN (0.45) | CRBNDDB1 | |
| SCHEMBL25031321 | 0.84 | HTR1A (0.49) | HTR7HTR1ACRBNDDB1ADAMTS5 | |
| SCHEMBL25825109 | 0.83 | CRBN (0.42) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL25031287 | 0.83 | HTR7 (0.46) | HTR7HTR1ACRBNDDB1ADAMTS5 | |
| SCHEMBL25024437 | 0.82 | CRBN (0.47) | HTR7HTR1ACRBNDDB1 | |
| SCHEMBL25824646 | 0.80 | ADAMTS5 (0.40) | HTR7HTR1ACRBNCCNCCDK8 | |
| SCHEMBL25034991 | 0.77 | CRBN (0.39) | HTR7HTR1ACRBNDDB1 | |
| SCHEMBL30938263 | 0.77 | CRBN (0.62) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL29179838 | 0.77 | DDB1 (0.51) | HTR7HTR1ACRBNDDB1ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |