Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 8/20 | 0.39 |
| ▸ | HTR1A | P08908 | 8/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25031287 | 0.83 | HTR7 (0.46) | ADAMTS5HTR7HTR1ACRBN | |
| SCHEMBL30475475 | 0.82 | HTR7 (0.44) | ADAMTS5NR3C1PGRSLC6A4KCNH2 | |
| SCHEMBL25034750 | 0.82 | HTR7 (0.44) | ADAMTS5NR3C1PGRSLC6A4KCNH2 | |
| SCHEMBL25031321 | 0.82 | HTR1A (0.49) | ADAMTS5HTR7HTR1ACRBN | |
| SCHEMBL25824324 | 0.81 | ALDH1A1 (0.42) | PDE3BPDE3AADAM17ALDH1A1KMT2A | |
| SCHEMBL25033930 | 0.81 | HTR7 (0.42) | ADAMTS5NR3C1PGRSLC6A4KCNH2 | |
| SCHEMBL25035481 | 0.80 | HTR7 (0.41) | ADAMTS5HTR7HTR1ACCNCCDK8 | |
| SCHEMBL30938263 | 0.76 | CRBN (0.62) | ALDH1A1CCNCCDK8IRAK1NTRK3 | |
| SCHEMBL26814219 | 0.76 | CRBN (0.62) | ALDH1A1CCNCCDK8IRAK1NTRK3 | |
| SCHEMBL29179852 | 0.76 | DDB1 (0.57) | ADAMTS5HTR7HTR1ACRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219966-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219966-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | ADAMTS5 3105/4885NR3C1 3528/4885PGR 2585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.