SCHEMBL25049002

SCHEMBL25049002

CN(CCCNCCc1ccc(F)cc1)C[C@H]1C[C@@H](n2cc(C3=CCCC=C3)c3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 3/20 0.31
▸ PRMT5 O14744 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25048478 0.88 METTL3 (0.35) METTL3PRMT5
SCHEMBL30940989 0.88 METTL3 (0.35) METTL3PRMT5
SCHEMBL25047887 0.86 METTL3 (0.39) METTL3PRMT5
Hydrochloric Acid SCHEMBL30940756 0.85 METTL3 (0.39) METTL3PRMT5
SCHEMBL25048574 0.85 ADK (0.32) METTL3PRMT5
SCHEMBL25048580 0.82 PRMT5 (0.32) METTL3PRMT5
SCHEMBL25049371 0.82 CA2 (0.34) METTL3PRMT5
SCHEMBL30941294 0.80 METTL3 (0.34) METTL3PRMT5
SCHEMBL30941243 0.79 DOT1L (0.37) METTL3PRMT5
SCHEMBL25049233 0.77 PRMT5 (0.32) METTL3PRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023017152-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2023-02-16 — — WO disclosed
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