Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8977857 | 0.92 | LMNA (0.77) | LMNANPSR1MAPK1DRD3GAA | |
| Alphaprodine SCHEMBL25054 | 0.88 | LMNA (0.97) | LMNANPSR1MAPK1DRD3GAA | |
| Betaprodine SCHEMBL186644 | 0.88 | LMNA (0.97) | LMNANPSR1MAPK1DRD3GAA | |
| Betaprodine SCHEMBL25053 | 0.88 | LMNA (0.97) | LMNANPSR1MAPK1DRD3GAA | |
| Betaprodine SCHEMBL248367 | 0.88 | LMNA (0.97) | LMNANPSR1MAPK1DRD3GAA | |
| Alphaprodine SCHEMBL8818643 | 0.87 | LMNA (1.00) | LMNANPSR1MAPK1DRD3GAA | |
| Betaprodine SCHEMBL394431 | 0.87 | LMNA (1.00) | LMNANPSR1MAPK1DRD3GAA | |
| Betaprodine SCHEMBL1649307 | 0.86 | LMNA (0.93) | LMNANPSR1MAPK1DRD3GAA | |
| Proheptazine SCHEMBL25539 | 0.81 | LMNA (0.84) | LMNANPSR1MAPK1DRD3GAA | |
| Betaprodine SCHEMBL4283575 | 0.78 | LMNA (0.77) | LMNANPSR1MAPK1DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501774-B1 | Preparation of substituted tetrahydropyridines | LILLY CO ELI (US) | 1996-04-10 | — | — | EP | disclosed |
| US-5498718-A | FROM 4-CARBONATE-1,3,4-SUBSTITUTED PIPERIDINE | ELI LILLY AND COMPANY (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0501774-A1 | Preparation of substituted tetrahydropyridines | ELI LILLY AND COMPANY (US) | 1992-09-02 | — | — | EP | disclosed |
| US-5136040-A | Chemical intermediates | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |