Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.38 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18587449 | 0.88 | ESR1 (0.53) | SNCANOTUMGPR84PTGS1PTGS2 | |
| SCHEMBL19792442 | 0.85 | NOTUM (0.54) | SNCANOTUMGPR84PTGS1PTGS2 | |
| SCHEMBL19317252 | 0.84 | NOTUM (0.49) | NOTUMGPR84PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL1627406 | 0.80 | SNCA (0.56) | SNCANOTUMGPR84SMN1; SMN2ALDH1A1 | |
| SCHEMBL19287002 | 0.79 | NOTUM (0.45) | NOTUMGPR84PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL16981889 | 0.79 | NOTUM (0.45) | NOTUMGPR84PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL7944188 | 0.78 | SNCA (0.53) | SNCANOTUMGPR84MAPTMAPK14 | |
| SCHEMBL25065122 | 0.77 | SNCA (0.46) | SNCAESR1ESR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL21035191 | 0.75 | ALDH1A1 (0.59) | SNCAPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4285976 | 0.75 | KDM4E (0.51) | SNCAGPR84SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230054781-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230054781-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | SNCA 1441/4885NOTUM 4496/4885GPR84 4325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.