Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26295651 | 0.89 | CHRM3 (0.40) | DRD2DRD3CHRM3GNAI3GNAO1 | |
| SCHEMBL26269832 | 0.87 | FAAH (0.42) | DRD2DRD3CHRM3GNAI3GNAO1 | |
| SCHEMBL25075014 | 0.87 | GNAI3 (0.42) | DRD2DRD3CHRM3GNAI3GNAO1 | |
| SCHEMBL26494238 | 0.84 | HPGD (0.44) | DRD2DRD3SIGMAR1CHRM3 | |
| SCHEMBL24475418 | 0.82 | HRH3 (0.46) | PIK3CDDRD2DRD3SIGMAR1CHRM3 | |
| SCHEMBL680019 | 0.82 | PIK3CD (0.45) | PIK3CDCYP1A2TDP1 | |
| SCHEMBL25075427 | 0.82 | SIGMAR1 (0.37) | DRD2DRD3SIGMAR1 | |
| SCHEMBL24865977 | 0.81 | HSD11B1 (0.51) | PIK3CDDRD2DRD3SIGMAR1CHRM3 | |
| SCHEMBL27097486 | 0.81 | SIGMAR1 (0.47) | SIGMAR1CHRM3CYP1A2TDP1 | |
| SCHEMBL26295666 | 0.81 | DRD2 (0.41) | DRD2DRD3CHRM3GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |