SCHEMBL250886

SCHEMBL250886

O=C(O)NC(c1ccccc1)C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TACR3 P29371 1/20 0.49
LMNA P02545 2/20 0.47
CTSL P07711 4/20 0.46
PRCP P42785 1/20 0.45
CTSS P25774 1/20 0.44
CTSK P43235 1/20 0.44
HTT P42858 1/20 0.42
TRPM8 Q7Z2W7 1/20 0.41
ALDH1A1 P00352 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CXCR1 P25024 1/20 0.40
CXCR2 P25025 1/20 0.40
PDE2A O00408 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16989173 0.88 TACR3 (0.49) TACR3LMNACTSLPRCPCTSS
SCHEMBL16989172 0.88 TACR3 (0.49) TACR3LMNACTSLPRCPCTSS
SCHEMBL10338251 0.85 GAA (0.50) TACR3LMNACTSLPRCPCTSS
SCHEMBL8689902 0.85 LMNA (0.45) TACR3LMNACTSLHTTALDH1A1
SCHEMBL17777055 0.85 TACR3 (0.47) TACR3LMNACTSLPRCPCTSS
SCHEMBL30152267 0.82 CTSL (0.45) TACR3LMNACTSLPRCPCTSS
SCHEMBL11256205 0.82 HTT (0.53) TACR3LMNACTSLPRCPCTSS
SCHEMBL8689297 0.80 LMNA (0.49) TACR3LMNACTSLPRCPCTSS
SCHEMBL1953208 0.78 MAPK1 (0.48) LMNAHTTALDH1A1SMN1; SMN2KMT2A
SCHEMBL2397321 0.78 CTSL (0.44) TACR3LMNACTSLCTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3368544-A1 PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII H. Hoffnabb-La Roche Ag (CH) 2018-09-05 EP disclosed
WO-2017072062-A1 PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII F. HOFFMANN-LA ROCHE AG (CH) 2017-05-04 WO disclosed
EP-3080103-A1 BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY Biogen MA Inc. (US) 2016-10-19 EP disclosed
WO-2015089337-A1 BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY BIOGEN IDEC MA INC. (US) 2015-06-18 WO disclosed
EP-2401275-A1 NOVEL BRONCHODILATING DIAZAHETEROARYLS Respiratorius AB (SE) 2012-01-04 EP disclosed
WO-2010097410-A1 NOVEL BRONCHODILATING DIAZAHETEROARYLS RESPIRATORIUS AB (SE) 2010-09-02 WO disclosed
EP-1737811-A4 CETP INHIBITORS MERCK & CO INC (US) 2009-06-17 EP disclosed
EP-1737811-A1 CETP INHIBITORS Merck & Co., Inc. (US) 2007-01-03 EP disclosed
US-6967196-B1 Sulfonamide compounds and uses thereof BRISTOL-MYERS SQUIBB COMPANY (US) 2005-11-22 US disclosed
WO-2005100298-A1 CETP INHIBITORS MERCK & CO., INC. (US) 2005-10-27 WO disclosed
US-5747420-A HERBICIDES NIHON BAYER AGROCHEM K.K. (JP) 1998-05-05 US disclosed
EP-0711761-A1 Tetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1996-05-15 EP disclosed