Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 11/20 | 0.37 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CDK1 | P06493 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | CDK4 | P11802 | 2/20 | 0.31 |
| ▸ | CDK7 | P50613 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2509200 | 1.00 | CXCR2 (0.37) | CXCR2CX3CR1MAT2ANPSR1BRAF | |
| SCHEMBL23547320 | 0.81 | PDE10A (0.40) | — | |
| SCHEMBL29931161 | 0.81 | PDE10A (0.40) | — | |
| SCHEMBL7486804 | 0.79 | CTSK (0.31) | — | |
| SCHEMBL7476102 | 0.77 | CRHR1 (0.40) | — | |
| SCHEMBL7474237 | 0.74 | KCNH2 (0.40) | — | |
| SCHEMBL2510236 | 0.73 | KDM4E (0.41) | CDK2 | |
| SCHEMBL12197591 | 0.73 | CRHR1 (0.36) | — | |
| SCHEMBL29861176 | 0.72 | MAT2A (0.31) | CXCR2MAT2A | |
| SCHEMBL28767108 | 0.72 | MAT2A (0.31) | CXCR2MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552921-B1 | PURINE COMPOUNDS | LILLY CO ELI (US) | 2015-10-07 | — | — | EP | disclosed |
| US-8759360-B2 | Purine compounds | ELI LILLY AND COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759360-B2 | Purine compounds | ELI LILLY AND COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759360-B2 | Purine compounds | ELI LILLY AND COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| WO-2011123372-A1 | PURINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2011-10-06 | — | — | WO | disclosed |
| US-20110245255-A1 | PURINE COMPOUNDS | ELI LILLY AND COMPANY | 2011-10-06 | — | — | US | disclosed |
| US-20110245255-A1 | PURINE COMPOUNDS | ELI LILLY AND COMPANY | 2011-10-06 | — | — | US | disclosed |
| US-20110245255-A1 | PURINE COMPOUNDS | ELI LILLY AND COMPANY | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245255-A1 | PURINE COMPOUNDS | P2RX1, P2RX3, P2RX7 | CXCR2 254/4885CX3CR1 586/4885MAT2A 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.