Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL3701419 | 1.00 | HSD17B10 (0.52) | HSD17B10TDP1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL4507841 | 0.97 | HSD17B10 (0.50) | HSD17B10TDP1TSHRTP53EGLN1 | |
| Fumaric Acid SCHEMBL9248586 | 0.97 | HSD17B10 (0.50) | HSD17B10TDP1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL10493320 | 0.90 | HSD17B10 (0.70) | HSD17B10TDP1TSHRTP53EGLN1 | |
| SCHEMBL1014778 | 0.87 | HCAR2 (0.52) | HSD17B10TDP1TSHRTP53EGLN1 | |
| SCHEMBL4168638 | 0.87 | HCAR2 (0.52) | HSD17B10TDP1TSHRTP53EGLN1 | |
| Monomethyl Fumarate SCHEMBL7123923 | 0.87 | HCAR2 (0.71) | HSD17B10TDP1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL713343 | 0.82 | TSHR (0.64) | HSD17B10TDP1TSHRTP53EGLN1 | |
| Fumaric Acid SCHEMBL713345 | 0.82 | TSHR (0.64) | HSD17B10TDP1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL342490 | 0.82 | TSHR (0.64) | HSD17B10TDP1TSHRTP53EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 335 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024048429-A1 | COSMETIC PROCESS USING PARTICLE WITH MICROPROTRUSION | L'OREAL (FR) | 2024-03-07 | — | — | WO | claimed |
| WO-2020017441-A1 | MICRONEEDLE SHEET | L'OREAL (FR) | 2020-01-23 | — | — | WO | claimed |
| WO-2020004666-A1 | COSMETIC PROCESS USING MICRONEEDLE SHEET | L'OREAL (FR) | 2020-01-02 | — | — | WO | claimed |
| EP-2702981-B1 | LIQUID COSMETIC MATERIAL | MITSUBISHI PENCIL CO (JP) | 2019-02-13 | — | — | EP | claimed |
| WO-2018092033-A1 | AN INSECTICIDAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF | INDOFIL INDUSTRIES LIMITED (IN) | 2018-05-24 | — | — | WO | claimed |
| WO-2017162822-A1 | COMPOSITIONS FOR MUCOSAL ADHESION AND USES THEREOF | BIONANOPLUS, S.L. (ES) | 2017-09-28 | — | — | WO | claimed |
| EP-3222270-A1 | COMPOSITIONS FOR MUCOSAL ADHESION AND USES THEREOF | Bionanoplus, S.L. (ES) | 2017-09-27 | — | — | EP | claimed |
| US-20170224629-A1 | COMPOSITIONS FOR NAIL AND SKIN TREATMENT | YISSUM RES DEV CO (IL) | 2017-08-10 | — | — | US | claimed |
| EP-2391344-B1 | COMPOSITIONS FOR NAIL AND SKIN TREATMENT | YISSUM RES DEV COMPANY OF THE HEBREW UNIV OF JERUSALEM (IL) | 2017-07-12 | — | — | EP | claimed |
| US-9668987-B2 | Compositions for nail and skin treatment | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2017-06-06 | — | — | US | claimed |
| WO-2010086725-A1 | COMPOSITIONS FOR NAIL AND SKIN TREATMENT | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2010-08-05 | — | — | WO | claimed |
| CN-1766027-A | The method that is used to make improved cerium oxide abrasive particles and comprises this grains of composition | SAMSUNG ELECTRONICS CO LTD (KR) | 2006-05-03 | — | — | CN | claimed |
| EP-0604537-A4 | ADHESIVE PRODUCTS. | SMITHKLINE BEECHAM CORP (US) | 1995-02-15 | — | — | EP | claimed |
| EP-0604537-A1 | ADHESIVE PRODUCTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-06 | — | — | EP | claimed |
| US-5281393-A | First layer of absorbent matrix having dispersed therein a water insoluble complex of copper and a polymer, which combines with hemoglobin and bilirubin, and second layer of reagent which reacts with other analytes | MILES INC. (US) | 1994-01-25 | — | — | US | claimed |
| US-5229296-A | Using polymers with multiple carboxyl groups whose complexes form insoluble products with hemoglobin and bilirubin from blood or serum samples | MILES INC. (US) | 1993-07-20 | — | — | US | claimed |
| EP-0549970-A1 | Use of polymer-copper complex to reduce interference of biological substances | Bayer Corporation (US) | 1993-07-07 | — | — | EP | claimed |
| WO-1993006144-A1 | ADHESIVE PRODUCTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-01 | — | — | WO | claimed |
| US-5082656-A | Antibiotic, polymer, plasticizer, solvent | ABBOTT LABORATORIES (US) | 1992-01-21 | — | — | US | claimed |
| US-4933246-A | Electrophotographic imaging member with a copolymer blocking layer | XEROX CORPORATION (US) | 1990-06-12 | — | — | US | claimed |