SCHEMBL25138367

SCHEMBL25138367

O=C1COc2ccc(N3CCN(c4ccc5cc[nH]c5c4)CC3)cc2N1Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 5/20 0.49
BRD4 O60885 2/20 0.46
HTR6 P50406 1/20 0.44
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
HTR1A P08908 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
HTR1D P28221 1/20 0.42
HTR1B P28222 1/20 0.42
CYP2C19 P33261 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
MAPT P10636 2/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 2/20 0.42
MEN1 O00255 1/20 0.42
LMNA P02545 1/20 0.42
KMT2A Q03164 1/20 0.42
MAPK14 Q16539 1/20 0.40
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4674316 0.83 HTR6 (0.64) PIK3CGBRD4HTR6CYP1A2CYP3A4
SCHEMBL23768835 0.81 ALDH1A1 (0.52) CYP3A4CYP2C9CYP2C19MAPTKDM4E
SCHEMBL29979599 0.81 ALDH1A1 (0.52) CYP3A4CYP2C9CYP2C19MAPTKDM4E
SCHEMBL23769073 0.74 ITGB3 (0.51) BRD4
SCHEMBL29979318 0.74 ITGB3 (0.51) BRD4
SCHEMBL3660420 0.73 BRD4 (0.58) PIK3CGBRD4HTR6L3MBTL1MAPT
SCHEMBL4678275 0.73 HTR6 (0.50) PIK3CGHTR6L3MBTL1KDM4EALDH1A1
SCHEMBL6578101 0.72 DRD2 (0.57) HTR1ADRD2DRD4DRD3
SCHEMBL23768817 0.72 ITGB3 (0.44) PIK3CGBRD4
SCHEMBL29979909 0.72 ITGB3 (0.44) PIK3CGBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230124361-A1 SMALL MOLECULE STING ANTAGONISTS CURADEV PHARMA PVT. LTD. (IN) 2023-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230124361-A1 SMALL MOLECULE STING ANTAGONISTS STING1, CGAS, MAVS PIK3CG 1846/4885BRD4 3179/4885HTR6 3635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.