Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16579816 | 1.00 | ADRA1A (0.61) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL25146459 | 0.98 | ADRA1A (0.58) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL25146989 | 0.93 | ADRA1A (0.50) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL8779381 | 0.85 | PRMT1 (0.59) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL11133946 | 0.85 | PRMT1 (0.59) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL515857 | 0.85 | PRMT1 (0.59) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL24686717 | 0.85 | PRMT1 (0.59) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL11137045 | 0.85 | PRMT1 (0.59) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL81977 | 0.85 | PRMT1 (0.59) | ADRA1APRMT1POLBEPHX2PLA2G2A | |
| SCHEMBL8779440 | 0.85 | PRMT1 (0.59) | ADRA1APRMT1POLBEPHX2PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230117680-A1 | CYCLOPHILIN D INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2023-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230117680-A1 | CYCLOPHILIN D INHIBITORS AND USES THEREOF | PPID, PPIF, PPIL1 | ADRA1A 2184/4885PRMT1 4221/4885POLB 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.