Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25146565 | 0.85 | CYP4F2 (0.62) | CYP4F2CYP4A11PTGS2FFAR1TDP1 | |
| SCHEMBL25146694 | 0.84 | CYP4F2 (0.51) | CYP4F2CYP4A11FFAR1TDP1RARB | |
| SCHEMBL23512545 | 0.84 | CYP4F2 (0.51) | CYP4F2CYP4A11FFAR1TDP1LMNA | |
| SCHEMBL25146355 | 0.82 | HRH3 (0.50) | CYP4F2CYP4A11PTGS2FFAR1PTGS1 | |
| SCHEMBL25146548 | 0.81 | FFAR1 (0.45) | CYP4F2CYP4A11PTGS2FFAR1TDP1 | |
| SCHEMBL764926 | 0.80 | CYP4F2 (0.68) | CYP4F2CYP4A11PTGS2TDP1PTGS1 | |
| SCHEMBL25146556 | 0.78 | FFAR1 (0.67) | PTGS2FFAR1PTGS1LMNACYP2C9 | |
| Isobutylbenzene SCHEMBL8032759 | 0.77 | ALDH1A1 (0.46) | PTGS2TDP1PTGS1LMNACYP2C9 | |
| SCHEMBL7930119 | 0.77 | ADRB2 (0.52) | CYP4F2CYP4A11PTGS2PTGS1LMNA | |
| SCHEMBL27811069 | 0.77 | TDP1 (0.51) | CYP4F2CYP4A11PTGS2TDP1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230117680-A1 | CYCLOPHILIN D INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2023-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230117680-A1 | CYCLOPHILIN D INHIBITORS AND USES THEREOF | PPID, PPIF, PPIL1 | CYP4F2 723/4885CYP4A11 413/4885PTGS2 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.