Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30364642 | 1.00 | PDCD1 (0.42) | PDCD1CD274ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25148692 | 0.88 | POLB (0.50) | PDCD1CD274TDP1POLBKLKB1 | |
| SCHEMBL25148803 | 0.87 | NR3C1 (0.40) | CD274TDP1POLBKLKB1 | |
| SCHEMBL25148734 | 0.82 | PDCD1 (0.44) | PDCD1CD274ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30364876 | 0.82 | PDCD1 (0.44) | PDCD1CD274ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30364609 | 0.77 | LMNA (0.41) | CD274ALDH1A1HPGDTSHRPOLB | |
| SCHEMBL21076572 | 0.76 | PDCD1 (0.40) | PDCD1CD274 | |
| SCHEMBL898708 | 0.70 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10HPGDNPSR1 | |
| SCHEMBL29320833 | 0.69 | PDCD1 (0.40) | PDCD1CD274ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2027363 | 0.69 | PDCD1 (0.52) | PDCD1CD274ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |