Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TEC | P42680 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30364759 | 0.87 | TRPV3 (0.38) | ROCK2TRPV3PARP1NR1H2NR1H3 | |
| SCHEMBL25149306 | 0.83 | PARP15 (0.42) | ROCK2ROCK1NNMTCDK8CDK19 | |
| SCHEMBL25148626 | 0.83 | PARP15 (0.42) | ROCK2ROCK1NNMTCDK8CDK19 | |
| SCHEMBL27906200 | 0.82 | TRPV3 (0.39) | ROCK2TRPV3PARP1POLBTBK1 | |
| SCHEMBL25149632 | 0.78 | NNMT (0.41) | ROCK2ROCK1NNMTGSK3BNR3C1 | |
| SCHEMBL30365013 | 0.76 | LMNA (0.40) | TRPV3POLB | |
| SCHEMBL25148803 | 0.72 | NR3C1 (0.40) | ROCK2ROCK1NNMTGSK3BNR3C1 | |
| SCHEMBL3544818 | 0.71 | NNMT (0.45) | ROCK2ROCK1NNMTPOLBTDP1 | |
| SCHEMBL26618866 | 0.70 | MAPK1 (0.41) | NNMTPARP1POLBEGFRTEC | |
| SCHEMBL28014566 | 0.70 | NNMT (0.51) | NNMTPARP1POLBTDP1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |